How to apply for Executive Director, Clinical Pharmacology/Pharmacometrics

About Recursion

Recursion is a clinical-stage company focused on treating rare diseases and oncology. The role is remote in the UK, and the company describes its clinical development team as innovative and dedicated to improving patients' lives. The job posting does not include details on company size, pipeline, or culture, so research these before applying.

About the role

This executive director role leads clinical pharmacology and pharmacometrics strategy for a portfolio of rare disease and oncology programs. You will design studies, perform modeling and simulation, author regulatory documents, and represent the company in health authority interactions. The impact is on accelerating therapies to patients by solving drug development problems and supporting product development plans.

A typical day

A typical day may involve leading clinical pharmacology strategy meetings, overseeing modeling and simulation activities, and authoring regulatory documents. You might also interact with cross-functional teams and health authorities. The job posting does not specify daily routines, so ask about typical workflows during the interview.

Who Recursion is looking for

• Extensive experience in clinical pharmacology and pharmacometrics, with a track record in rare disease and oncology programs.
• Proven ability to develop and execute clinical pharmacology strategies across Phase 1-3 studies.
• Strong skills in modeling and simulation tools to support decision-making and expedite development.
• Experience authoring regulatory documents such as IBs, INDs, and NDAs, and acting as a clinical pharmacology expert in health authority interactions.

Tips for this application

• Highlight specific examples of clinical pharmacology strategies you developed for rare disease or oncology programs, including outcomes.
• Detail your experience with modeling and simulation tools and how you used them to solve drug development problems.
• List regulatory submissions you authored or contributed to, such as INDs or NDAs, and any health authority interactions you led.
• Emphasize cross-functional collaboration with teams like DMPK, translational modeling, and clinical study teams.
• If you have remote work experience in the UK, mention it, as the role is remote in the UK.

What to cover in your cover letter

Focus on your clinical pharmacology and pharmacometrics leadership in rare disease and oncology. Provide concrete examples of developing strategies that accelerated development. Describe your experience with regulatory submissions and health authority interactions. Mention your ability to design clinical studies and perform modeling and simulation.

Research before applying

• Recursion's pipeline and focus areas in rare disease and oncology, including any public disclosures.
• The company's recent regulatory submissions or clinical trial milestones.
• Recursion's approach to clinical development and any published materials on their clinical pharmacology or pharmacometrics work.
• The UK remote work policies and any legal or tax implications for remote employment.

Likely interview topics

Based on the job description, expect questions about:

• Describe a clinical pharmacology strategy you developed for a rare disease or oncology program and how it impacted development timelines.
• Walk through a modeling and simulation project you led to solve a drug development question.
• How have you contributed to regulatory documents like INDs or NDAs, and what was your role in health authority interactions?
• Give an example of cross-functional collaboration with DMPK or translational teams to advance a program.
• How do you approach designing Phase 1-3 studies from a clinical pharmacology perspective?

Common mistakes to avoid

• Submitting a generic cover letter that does not mention rare disease or oncology experience.
• Failing to provide specific examples of regulatory submissions or health authority interactions.
• Not demonstrating hands-on experience with modeling and simulation tools or clinical pharmacology strategy.