Senior Engineer I, Science

Core responsibilities:

• Design, develop, optimize, and validate a wide array of high-throughput in vitro ADME assays (e.g., solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction)
• Develop and perform mass spectrometry (LC-MS/MS, acoustic ejection mass spectrometry, or similar) analysis of samples from ADME assays, including method development and troubleshooting
• Analyze, interpret, and report complex ADME data, including calculating key pharmacokinetic parameters, and present results to inform go/no-go decisions
• Maintain detailed and accurate laboratory records, SOPs, and electronic notebooks while ensuring compliance with internal quality standards and safety regulations

This role accelerates drug discovery pipelines by providing timely, high-quality in vitro ADME data to guide lead optimization, helping address global health challenges through biotechnology.

Required qualifications:

• Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or related field with 2+ years industry experience, OR Master's degree with 5+ years industry experience
• Extensive hands-on experience with LC-MS or acoustic MS in high-throughput settings
• Proven track record in developing and running automated in vitro ADME assays using state-of-the-art laboratory automation
• Strong theoretical and practical knowledge of drug metabolism pathways and DMPK

Base salary range: $115,000 - $165,000, company stock awards, comprehensive benefits package including medical, dental & vision coverage, health spending accounts, voluntary benefits, leave of absence policies, 401(k) program with employer contribution, 8 paid holidays plus full-week winter shutdown, unlimited Paid Time Off policy.

Ginkgo Bioworks' mission is to make biology easier to engineer by constructing, editing, and redesigning the living world to address global challenges in health, energy, food, materials, and more through automated bioengineering foundries.