Senior CADD Scientist

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Senior CADD Scientist to join our team, working directly with scientists  in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.

**What You Will Do (Key Responsibilities)**

•
Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.

•
Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.

•
Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.

•
Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.

•
Adapt to a fast-paced environment where innovation and quick iteration are encouraged.

**What you’ll bring**

•
PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.

•
Deep understanding of structure-based drug design and protein-ligand interactions.

•
Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.

•
Minimum of 2+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.

•
Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too.

**What we offer**

•
Competitive Pay

•
Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)

•
Stock Option Eligibility

•
401(k) Plan

•
Open PTO Policy

•
Paid Company Holidays

•
Subsidized lunch and snacks at our offices

**About Genesis Molecular AI**

Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company’s generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.

Genesis Molecular AI is assembling a world-class computational chemistry team to revolutionize drug discovery through cutting-edge machine learning and biophysical simulation. We are seeking a Senior CADD Scientist to join our team, working directly with scientists  in our state-of-the-art wet lab and with our distributed computational chemistry and CADD science teams across the US.

**What You Will Do (Key Responsibilities)**

•
Utilize a combination of industry-standard and proprietary AI-powered CADD tools to guide small molecule drug discovery programs across a diverse target portfolio, including novel targets with limited chemical precedents.

•
Use approaches like virtual screening, molecular simulation, and potency and ADMET prediction to support key decision-making in drug discovery efforts.

•
Collaborate closely with medicinal chemists in molecular design and the development of project-specific computational approaches.

•
Act as a cross-team connector, effectively communicating between our computational chemistry and medicinal chemistry teams to ensure seamless information flow and collaborative decision making.

•
Adapt to a fast-paced environment where innovation and quick iteration are encouraged.

**What you’ll bring**

•
PhD in Computational Chemistry, Structural Biology, or a related field. This particular role may also be suitable for PhD-level scientists with degrees in organic or medicinal chemistry with extensive experience in the lab, who have transitioned into industry roles in CADD.

•
Deep understanding of structure-based drug design and protein-ligand interactions.

•
Proficiency with industry-standard CADD tools such as MOE, PyMOL, and Schrodinger Suite.

•
Minimum of 2+ years of industry experience as a CADD scientist in pharma or biotech, with hands-on experience in active drug discovery programs.

•
Onsite in our San Diego lab is preferred for this role, to be able to collaborate with our scientists. We are open to remote team members too.

**What we offer**

•
Competitive Pay

•
Health Care Plans (including Medical, Dental, and Vision, fully covered for the employees)

•
Stock Option Eligibility

•
401(k) Plan

•
Open PTO Policy

•
Paid Company Holidays

•
Subsidized lunch and snacks at our offices

**About Genesis Molecular AI**

Genesis Molecular AI is pioneering foundation models for molecular AI to unlock a new era of drug design and development. The company’s generative and predictive AI platform, GEMS (Genesis Exploration of Molecular Space), integrates AI and physics into industry-leading models to generate and optimize drug molecules, including the breakthrough generative diffusion model Pearl for structure prediction. Genesis has raised over $300 million from leading AI, tech and life science-focused investors, signed multiple AI-focused research collaborations with major pharma partners, and is deploying GEMS to advance an internal therapeutics pipeline for a variety of high-impact targets.

Genesis is headquartered in Burlingame, CA, with a fully integrated laboratory in San Diego. We are proud to be an inclusive workplace and an Equal Opportunity Employer.