Application Guide

How to Apply for Director Protein & ADC Analytics

at BioNTech

🏢 About BioNTech

BioNTech is a pioneering biotechnology company that gained global recognition for developing the first mRNA-based COVID-19 vaccine, demonstrating its ability to rapidly translate cutting-edge science into life-saving treatments. The company maintains a strong focus on oncology and infectious diseases, with a pipeline that includes personalized cancer immunotherapies and next-generation infectious disease vaccines. Working at BioNTech offers the opportunity to contribute to revolutionary medical breakthroughs in a highly innovative and fast-paced environment.

About This Role

As Director of Protein & ADC Analytics, you will lead analytical strategy for antibody-drug conjugate (ADC) development programs, ensuring GMP compliance and regulatory readiness from early to late-stage development. This role directly impacts patient access to novel cancer therapies by establishing robust analytical methods for linker-payload characterization and supporting regulatory submissions. You'll serve as the analytical subject matter expert for health authority interactions, making this position critical to BioNTech's ADC portfolio success.

💡 A Day in the Life

A typical day might involve reviewing analytical data from ADC characterization studies, providing expert input on regulatory submission documents, and leading discussions with cross-functional teams about analytical strategy for ongoing development programs. You could spend time troubleshooting method performance issues, preparing for health authority interactions, or mentoring junior analysts on GMP-compliant analytical practices.

🚀 Application Tools

Generate Cover Letter

AI-powered, tailored for BioNTech

Interview Prep

Practice questions for this role

🎯 Who BioNTech Is Looking For

  • Ph.D. in Analytical Chemistry with 10+ years in regulated biopharmaceutical environments, specifically with ADC or small molecule linker-payload analytical development
  • Deep hands-on expertise with HPLC, GC, mass spectrometry, and NMR for ADC characterization, plus proven experience authoring Common Technical Document (CTD) sections for regulatory submissions
  • Demonstrated leadership in analytical method development, validation, and transfer within GMP environments for both early and late-stage programs
  • Strong regulatory experience including direct interaction with health authorities (EMA/FDA) and preparation of responses to regulatory questions

📝 Tips for Applying to BioNTech

1

Quantify your ADC analytical experience: specify how many ADC programs you've supported, regulatory submissions you've contributed to, and methods you've developed/validated

2

Highlight specific BioNTech-relevant experience: mention any work with mRNA-based therapeutics, oncology pipelines, or European regulatory submissions given the Germany location

3

Demonstrate knowledge of BioNTech's ADC pipeline: reference specific programs like BNT323/HER2-targeted ADC or their collaboration with Regeneron on BNT311

4

Emphasize GMP compliance experience in both early and late-stage development, as this is explicitly mentioned in the job description

5

Include specific analytical techniques mentioned in the requirements (HPLC, GC, MS, NMR, IR) with examples of how you've applied them to ADC characterization

✉️ What to Emphasize in Your Cover Letter

["Your direct experience with ADC linker-payload analytical chemistry and how it aligns with BioNTech's focus on next-generation cancer therapies", "Specific examples of regulatory submissions you've contributed to (especially CTD modules) and interactions with health authorities", 'Experience bridging early and late-stage analytical development while maintaining GMP compliance throughout the product lifecycle', "How your expertise in method development, validation, and transfer can support BioNTech's ambitious ADC pipeline and regulatory strategy"]

Generate Cover Letter →

🔍 Research Before Applying

To stand out, make sure you've researched:

  • → BioNTech's current ADC pipeline and partnerships (particularly their oncology focus and collaborations with Regeneron, Genmab)
  • → The company's regulatory history with health authorities, especially their experience with EMA submissions from their German headquarters
  • → Recent publications or presentations by BioNTech scientists on ADC analytics or related analytical challenges
  • → BioNTech's corporate culture and values, particularly their emphasis on scientific innovation and rapid translation to patients

💬 Prepare for These Interview Topics

Based on this role, you may be asked about:

1 Detailed technical discussion of ADC analytical challenges: linker-drug ratio determination, payload quantification, and aggregation analysis
2 Scenario-based questions about responding to health authority questions on analytical methods for ADC submissions
3 Experience with analytical method transfer between sites or to CMOs, particularly in international settings
4 Knowledge of current regulatory expectations for ADC characterization from EMA and FDA perspectives
5 How you would approach establishing analytical control strategies for both early-phase and commercial ADC programs
Practice Interview Questions →

⚠️ Common Mistakes to Avoid

  • Presenting only large molecule (antibody) analytical experience without emphasizing small molecule/linker-payload expertise
  • Generic analytical chemistry experience without specific examples related to ADCs or highly regulated GMP environments
  • Failing to demonstrate knowledge of both early and late-stage development requirements, as the role explicitly covers both

📅 Application Timeline

This position is open until filled. However, we recommend applying as soon as possible as roles at mission-driven organizations tend to fill quickly.

Typical hiring timeline:

1

Application Review

1-2 weeks

2

Initial Screening

Phone call or written assessment

3

Interviews

1-2 rounds, usually virtual

✓

Offer

Congratulations!

Ready to Apply?

Good luck with your application to BioNTech!

← Back to Job Listing Apply Now →