Associate Director/Director, Medicinal Chemistry

Associate Director/Director, Medicinal Chemistry

About

• Design and implement medicinal chemistry strategies from early discovery through candidate selection, leveraging structure- and property-based design principles.
• Drive compound design and optimization by integrating SAR, ADME/DMPK, pharmacology, and safety data to meet target product profiles.
• Partner with computational chemistry teams to apply computational approaches to molecular design and optimization.
• Manage and direct external CRO partnerships, including oversight of complex synthetic routes, timelines, data quality, and compound delivery and registry.
• Collaborate with biology teams to interpret data and guide decision-making in a continuous and iterative design, synthesize, test, learn loop.
• Collaborate with legal and IP teams to draft, review, and support patent filings related to medicinal chemistry innovations.

Requirements

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Benefits

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About the Company

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This role creates positive change by pioneering novel therapeutic modalities to transform human health, potentially curing intractable diseases and improving human health through innovative biotechnology.

Required qualifications:

• PhD in Organic Chemistry or Medicinal Chemistry with 8-10+ years of industry experience in small molecule drug discovery within a pharma or biotech environment.
• Track record of delivering on small molecule heterobifunctional and/or induced proximity programs (e.g., PROTACs).
• Deep expertise in medicinal chemistry, including synthetic organic chemistry, SAR analysis, ADME, pharmacokinetics, and drug design principles.
• Proven ability to lead projects and cross-functional teams.
• Excellent communication skills with the ability to convey complex scientific concepts.
• Experience managing external CROs and contributing as a chemistry leader.

Compensation and benefits:

• Salary range: $154,000 - $236,500
• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. The company has originated and fostered more than 100 scientific ventures addressing humanity's most urgent challenges.