Associate Director/Director, Computational Chemistry

Core responsibilities:

• Play a central role in the design and optimization of heterobifunctional small molecules
• Work closely with medicinal chemists, biologists, and in vivo pharmacologists to develop and apply computational tools to guide molecular design decisions
• Contribute directly to molecular ideation, property optimization, and compound prioritization with focus on heterobifunctional molecules
• Apply computational insights to shape experimental strategy in a fast-paced startup environment

This role contributes to creating new therapeutic modalities beyond traditional small molecules, with the potential to transform human health by addressing urgent medical challenges.

Required qualifications:

• PhD in Chemistry, Medicinal Chemistry, Computational Chemistry, or related discipline with 5+ years of relevant industry experience
• Hands-on experience in computational medicinal chemistry or structure-based drug design
• Demonstrated ability to propose and evaluate synthetically actionable molecular designs
• Experience using cheminformatics tools for compound design, analysis and prioritization
• Strong collaboration and communication skills for interdisciplinary teamwork

Compensation and benefits:

• Salary range: $176,000 - $253,000
• Healthcare coverage
• Annual incentive program
• Retirement benefits
• Broad range of other benefits

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies with the potential for multiple products that transform human health or sustainability. Since 2000, Flagship has originated and fostered more than 100 scientific ventures addressing humanity's most urgent challenges.